Escherichia coli: Chapter 12. Adhesive pili of the chaperone-usher family [Kindle-editie] beoordelingen het boek quotes

The chaperone–usher (CU) pathway constitutes one of the most prevalent mechanisms for the assembly of adhesive pili on the surface of Gram-negative bacteria. Studies at the interface of genetics, biochemistry, and structural biology have detailed the functions of the chaperone and the usher, providing a step-by-step understanding of pilus biogenesis by this sophisticated molecular machine. Further work has elucidated the molecular basis of specificity in host recognition by CU pili. Snapshots in CU pilus assembly and CU pilus-mediated pathogenesis have unveiled necessary molecular details for the design and application of promising antibiotic compounds that may soon prevent and treat acute, chronic, and recurrent bacterial infections in humans.